Buy Neurontin Online Australia

NEURONTIN® (Gabapentin):

Additional means in the treatment of partial seizures with secondary generalization and without it in adults and children aged 3 years and older.

Gabapentin in clinically significant concentrations is not associated with other conventional drugs and neuro- receptors in the brain, including with GABAA-, gabab-, benzodiazepines, receptors or N- Application indication Treatment of neuropathic pain in adults over the age of 18 years; Monotherapy of partial convulsions with secondary generalization and without it in adults and children over 12 years of age; As an methyl-D- ( NMDA)-receptors.

Pharmacokinetics

Gabapentin absorbed from the digestive tract. After ingestion Cmax gabapentin in the plasma achieved through 2-3 H. Absolute bioavailability of about 60%. Reception at the same time with food (including high fat) has no effect on the pharmacokinetics of Gabapentin.

Gabapentin is not associated with plasma proteins and has Vd 57.7 L. In patients with epilepsy the concentration of gabapentin in the cerebrospinal fluid is 20% of the corresponding in plasma at the end of the dosing interval.

Gabapentin output only kidneys. Signs of Biotransformation Gabapentin in the human body is not found. Gabapentin does not induce oxidase involved in the metabolism of medicinal products. Withdrawal of the drug is best described with a linear model. T1/2 does not depend on the dose and is an average of 5-7 hours

Gabapentin clearance is reduced in the elderly and in patients with impaired kidney function. The constant of the speed of excretion, plasma and renal clearance gabapentin directly proportional to creatinine clearance.

Gabapentin is removed from the plasma in hemodialysis.

The values of plasma gabapentin concentrations in children were similar to adults.

Neuropathic Pain Treatment

In its structure, the Neuron tin (gabapentin) is similar to the neurotransmitter GABA (GABA; gamma-aminbutyric acid), which performs the function of a brake mediator in the central nervous system. However, the mechanism of action of Neurontin differs from that of several other drugs interacting with GABA receptors, including valproata (sodium valproate), barbiturates, benzodiazepines, GABA-transaminase inhibitors, GAMK seizure inhibitors. , GABA agonists and GABA dosage forms. Neurontin (gabapentin) in clinically significant concentrations is not associated with receptors of other common drugs or neurotransmitters, including GABA-A, GABA-B, benzodiazepines, glutamate, glycine or N-methyl-D-aspartata.

In the research of the tagged gabapentin in vitro new peptide receptors in the brain tissue of rats, including neocortex and hippocampus, which can indirectly influence the anticonvulsant activity of gabapentin and its derivatives, are identified. However, the structure and function of receptors are not fully explored.

In contrast to Fenitine and carbamazepine, Neurontin (gabapentin) does not interact with sodium channels in vitro.

Neurontin (gabapentin) partially weakened the effects of the agonist of the N-methyl-D-aspartate in some tests in vitro, but only in concentrations of more than 100 μmol, which is not achieved in vivo.

The use of gabapentin in rats led to an increase in the exchange of GABA in some parts of the brain; This effect was similar to that of sodium valproate, although it was observed in other parts of the brain.

In animals gabapentin easily penetrates into the tissue of the brain and prevents convulsions caused by the maximum electroshock, chemical preparations, including inhibitors of synthesis GABA, as well as due to genetic factors. Farmakokinetikanejrontin (gabapentin) absorbed from the digestive tract. Absorption is fast. Bioavailability Neurontin is not proportional dose and the increase in the dose is reduced (with a dose of 300 mg-60%, with 1600 mg-30%). After taking Neurontin inside Cmax gabapentin plasma is achieved through 2-3 hours reception of Neurontin at the same time with food (incl. High fat) has no effect on the pharmacokinetics of Gabapentin. The pharmacokinetics of Neurontin does not change when applied again. Concentrations of gabapentin in plasma were proportional to the dose of Neurontin in the application of 300 mg or 400 mg every 8 hours gabapentin passes through GEB, enters breast milk. The connection with plasma proteins is very low (less than 5%). The distribution volume is 57.7 L. In patients with epilepsy, the concentration of gabapentin in the cerebrospinal fluid is 20% of the corresponding Css in the plasma. Gabapentin displays the kidneys. Withdrawal from the plasma has Linear dependence. Metabolized to a very small extent. Gabapentin does not induce oxidase involved in the metabolism of medicinal products. T1/2 does not depend on the dose and is an average of 5-7 hours (with a dose of 300 mg-5.2 hours, with a dose of 400 mg-6.1 h).

Gabapentin clearance is reduced in the elderly and in patients with impaired kidney function. The constant of the speed of excretion, plasma and renal clearance gabapentin directly proportional to creatinine clearance. T1/2 at QC less than 30 ml/min-52 hours.

Neurontin (gabapentin) is removed from the plasma in hemodialysis.

Pharmacokinetic parameters were determined in 24 healthy children aged 4 to 12 years, in general concentrations of plasma gabapentin in children were similar to adults

Neurontin Indications for use

• Neurontin is used in epilepsy, including the ineffectiveness of standard anticonvulsants means: • Partial seizures (epileptic seizures) with secondary generalisation (Tonico-clone cramps) and without it in adults and children over 12 years ( monotherapy);
• Partial seizures (epileptic seizures) with secondary generalisation (Tonico-clone cramps) and without it in adults (additional means);
• resistant form of epilepsy in children over 3 years (additional means).
• Neuronal is used in neuropathic pain in patients over 18 years of age (treatment).
• Treatment of neuropathic pain in adults aged 18 years and older;
• monotherapy of partial convulsions with secondary generalisation and without it in adults and children over 12 years of age;
• As an additional means in the treatment of partial seizures with secondary generalisation and without it in adults and children aged 3 years and older.

Neurontin contraindications

• Children up to 3 years of age;
• Hypersensitivity to the Gabapentinu and other components of the drug.
• With caution should be used drug in renal failure.
• Children up to 3 years of age;
• Hypersensitivity to the Gabapentinu and other components of the drug.
• With caution should be used drug in renal failure.

Neurontin dosage

Neurontin designate inside regardless of the meal or with food. If you need to reduce the dose, cancel the drug or replace it with an alternative remedy, it should be done gradually for at least one week.

In neuropathic pain adults designate in the initial dose of 900 mg/in 3 admission equal doses; If necessary, depending on the effect, gradually increase the dose to the maximum-3.6 g/treatment can be started immediately with a dose of 900 mg/(300 mg 3/) or during the first 3 days dose can be increased gradually to 900 mg/according to the following scheme: 1 day-300 mg Drug 1 time/; Day 2-300 mg 2; Day 3-300 mg 3

In partial convulsions for adults and children over the age of 12 years effective dose from 900 mg to 3.6 g/therapy can start with a dose of 300 mg three times a day on the first day or increase gradually to 900 mg according to the scheme described above. In the subsequent dose can be increased to a maximum of 3.6 g/(divided into 3 equal admission). Good tolerance of the drug in doses up to 4.8 g/maximum interval between doses with three times admission of the drug should not exceed 12 hours to avoid the recurrence of seizures.

For children aged 3-12 years: the initial dose of the drug varies from 10 to 15 mg/kg/, the multiplicity of admission-3 in equal doses, the increase to an effective dose is spent approximately 3 days. The effective dose of Neurontin in children aged 5 years and older is 25-35 mg/kg/equal doses in 3 admission. The effective dose of Neurontin in children aged 3 to 5 years is 40 mg/kg/equal doses in 3 admission. Good tolerance of the drug in doses of up to 50 mg/kg/with prolonged use. The maximum interval between doses of the drug should not exceed 12 hours to avoid the recurrence of seizures.

Neurontin designate inside regardless of the meal or with food. If you need to reduce the dose, cancel the drug or replace it with an alternative remedy, it should be done gradually for at least one week.

In neuropathic pain adults designate in the initial dose of 900 mg/in 3 admission equal doses; If necessary, depending on the effect, gradually increase the dose to the maximum-3.6 g/treatment can be started immediately with a dose of 900 mg/(300 mg 3/) or during the first 3 days dose can be increased gradually to 900 mg/according to the following scheme: 1 day-300 mg Drug 1 time/; Day 2-300 mg 2; Day 3-300 mg 3

In partial convulsions for adults and children over the age of 12 years effective dose from 900 mg to 3.6 g/therapy can start with a dose of 300 mg three times a day on the first day or increase gradually to 900 mg according to the scheme described above. In the subsequent dose can be increased to a maximum of 3.6 g/(divided into 3 equal admission). Good tolerance of the drug in doses up to 4.8 g/maximum interval between doses with three times admission of the drug should not exceed 12 hours to avoid the recurrence of seizures.

For children aged 3-12 years: the initial dose of the drug varies from 10 to 15 mg/kg/, the multiplicity of admission-3 in equal doses, the increase to an effective dose is spent approximately 3 days. The effective dose of Neurontin in children aged 5 years and older is 25-35 mg/kg/equal doses in 3 admission. The effective dose of Neurontin in children aged 3 to 5 years is 40 mg/kg/equal doses in 3 admission. Good tolerance of the drug in doses of up to 50 mg/kg/with prolonged use. The maximum interval between doses of the drug should not exceed 12 hours to avoid the recurrence of seizures.

There is no need to control plasma gabapentin concentration. Neurontin can be used in combination with other anticonvulsant drugs without considering the change of its concentration in the plasma or the concentration of other anticonvulsants drugs in the serum.

Neurontin Side Effects

• In the treatment of neuropathic pain
• From the body as a whole: not less than 1%-accidental injuries, fatigue, back pain, flu-like syndrome, headache, infection, pain of various localization, peripheral edema, increasing body weight.
• On the part of the digestive system: not less than 1%-constipation, diarrhea, dry mouth, dyspepsia, flatulence, nausea, vomiting, abdominal pain.
• From the CNS and peripheral nervous system: not less than 1%-gait, amnesia, ataxia, confusion, dizziness, drowsiness, a disturbance of thinking, tremor.
• From the respiratory system: not less than 1%-shortness of breath, pharyngitis;
• Dermatological reactions: not less than 1%-skin rash.
• From the sensory organs: not less than 1%-amblyopia.
• In the treatment of partial cramps
• Neurontin is most often used in combination with other anticonvulsant means, so to determine which drug caused side effects (if such a connection at all) was impossible.
• From the body as a whole: not less than 1%-asthenia, general malaise, swelling of the face, fatigue, fever, headache, viral infection, peripheral edema, increase body weight.
• From the cardiovascular system: not less than 1%-symptoms of vaszodiatation or arterial hypertension.
• On the part of the digestive system: not less than 1%-flatulence, anorexia, gingivitis, abdominal pain, constipation, dental diseases, diarrhoea, dyspepsia, increased appetite, dry mouth or throat

Storage conditions

Store at room temperature 15-25 degrees, protect from children

Synonyms

With the usual bouts of pain in the life of each person. If we get bruised - pain is a signal that arises to prevent and stop the damage or neutralize the threat. What happens if pain occurs when there is no reason? Neuropathic pain is caused by damage to the nervous system. It occurs when there is no obvious reason. Neuropathic pain in 70% of cases is the consequences of illness. You need to understand that constant pain, even if it is not strong, is very bad for the mental state of a person. This leads to depression and increased anxiety. This greatly affects the daily life of a person. Such pains are very often associated with epilepsy. For a diagnosis, you need to be examined by a doctor, or when you do not self-medicate. Strictly follow the recommendations of your doctor. Most importantly, if you have neuropathic pain, you need to control and treat your illness. Follow the advice of your doctor.

Modern technologies allow to treat neuropathic pains with the help of medicines. Such drugs as Neurontin will allow to treat neuropathic pains. These types of pain are caused by diseases such as epilepsy and nerve trauma, stroke, rheumatoid arthritis, herpes zoster, cancer or alcoholism. And this is an incomplete list. Neuropathic pain can be cured. Even in difficult cases, modern medicine treats almost all types of neuropathic pain. Do not postpone going to the doctor and taking your prescribed medication. It may take you some time, but it's worth it. In time, start taking modern and effective medicines such as Neurontin. The task of the patient, to stop feeling suffering, not nervous, sleep well, get rid of anxiety. The pain does not go away immediately, for the treatment of neuropathic pains do not interrupt the treatment. Drug treatment is used for all forms of epilepsy. Therapy helps 30-40% of patients with complex epilepsy seizures, patients who have seizures do not completely prescribed additional drugs.

When neuropathic pain does not help the usual painkillers. Monotherapy is usually prescribed with pregabalin or gabapentin (Neurontin). This drug has the best tolerability, the almost complete lack of drug interactions and a low incidence of adverse events. It is effective in treating various neuropathic diseases. Do not despair if you are diagnosed with epilepsy. With the use of new drugs, this disease ceases to have a negative impact on human life. Attacks become less frequent. Epilepsy attacks themselves are harmless. You can injure yourself if you are busy with complex work, such as swimming, driving a car, working at height. If your doctor accurately identified the cause of the attack, it will significantly reduce the risks to your health and life. You yourself should adhere to the recommendations of your doctor, follow a sleep pattern and not overwork, avoid stress. Observing these simple rules you can, you can take control of seizures, lead a normal life and are no different from other people. At the moment, epilepsy is no longer a sentence. Remember that this article is not a treatment guide, and is for informational purposes only. Take care of your health and the health of your loved ones.

Benefits of clinical Application Gabapentin

In the context of the current trends in pharmacotherapy neuropathic pain and leading positions, which occupy currently in the treatment of this pathology antiepileptic drugs, in particular gabapentin, it is advisable to consider the benefits Clinical application of this drug in more detail.

Anticonvulsants in the treatment of chronic pain syndrome began to apply long ago-since the 1960s. It is known that initially antiepileptic drug was introduced in 1968 in clinical practice for treatment of trigeminal neuralgia (Yuryev K. L, 2004). The accumulated clinical experience testifies to high efficiency of application of this class of preparations in therapy of neuropathic pain, especially at such variants, as shooting or stinging pain. Anticonvulsants of the New Generation (gabapentin), devoid of many severe side effects inherent in their predecessors, opened a new era in pharmacotherapy neuropathological pain syndromes.

Gabapentin is a structural analogue of gamma-aminolbutyric acid (GABA) and was originally registered in 1994 as a antiepileptic agent. The first mention of the ability of gabapentin to reduce the intensity of pain syndrome refers to 1996, when in the journal "Neurology" A.Z. Segal and G. Rordorf described the clinical case with a decrease in the severity of post-herpettic pain in the 77-year-old Patient on the background of admission gabapentin dose of 900 mg/sut. In the future, the results of many randomized clinical trials confirmed the clinical efficacy of gabapentin in the treatment of patients with various forms of neuropathic pain, which was the basis for the inclusion of this Drug in the current European recommendations on pharmacotherapy neuropathic pain as a drug of the 1st line.

Neuropathic pain is a consequence of impaired interaction of nociceptive and antinociceptive systems caused by their defeat at different levels of the nervous system. In the pathogenesis of pain most studied the role of peripheral nerves, spine, posterior horn of the spinal cord, neurotransmitters pain, glutamate receptors, sodium and calcium channels.